Precipitous clearance of herpes simplex virus antigens from the peripheral nervous systems of experimentally infected C57BL/10 mice.

@article{Speck1998PrecipitousCO,
  title={Precipitous clearance of herpes simplex virus antigens from the peripheral nervous systems of experimentally infected C57BL/10 mice.},
  author={Peter Gerald Speck and Anthony F Simmons},
  journal={The Journal of general virology},
  year={1998},
  volume={79 ( Pt 3)},
  pages={
          561-4
        }
}
Clearance of herpes simplex virus (HSV) from spinal ganglia of experimentally infected mice is known to be dependent on CD8+ T-cells but not on destruction of infected neurons, consistent with a non-cytolytic Tc2 response in the peripheral nervous system. Here, we demonstrate the striking rapidity of such a response in C57BL/10 mice. The number of neurons containing viral DNA and viral antigens increased until 136 h after inoculation of virulent HSV type 1 (strain SC16) into flank skin… CONTINUE READING

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Herpes simplex viruses

  • R. J. Whitley
  • In Fields Virology,
  • 1996
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