Precipitation and Neutralization of Heparin from Different Sources by Protamine Sulfate

Abstract

Current therapeutic unfractionated heparin available in Europe and US is of porcine mucosal origin. There is now interest, specifically in the US, to use bovine mucosa as an additional source for the production of heparin. The anticoagulant action of heparin can be neutralized by protamine sulfate, and in this study the ability of protamine to bind and… (More)
DOI: 10.3390/ph10030059

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