Prechemotherapy differences in response inhibition in breast cancer patients compared to controls: A functional magnetic resonance imaging study

@article{Scherling2012PrechemotherapyDI,
  title={Prechemotherapy differences in response inhibition in breast cancer patients compared to controls: A functional magnetic resonance imaging study},
  author={Carole S. Scherling and Barbara Collins and Joyce Mackenzie and Catherine Helen Bielajew and Andra M. Smith},
  journal={Journal of Clinical and Experimental Neuropsychology},
  year={2012},
  volume={34},
  pages={543 - 560}
}
Prechemotherapy neuroimaging data are lacking in posttreatment cognitive impairment studies. Breast cancer patients and noncancer controls were scanned prior to chemotherapy during a response inhibition task. Task reaction times and error rates, as well as neuropsychological tests, hospital records, and salivary biomarkers, were investigated, yielding no significant group differences. Significant group differences observed for the functional magnetic resonance imaging (fMRI) data depended on… 
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References

SHOWING 1-10 OF 111 REFERENCES
Pre-Chemotherapy Differences in Visuospatial Working Memory in Breast Cancer Patients Compared to Controls: An fMRI Study
TLDR
This is the first fMRI investigation to reveal neurophysiological differences during visuospatial working memory between BC patients pre-chemotherapy and controls, and these results increase the knowledge about the effects of BC and related factors on the working memory network.
Prechemotherapy alterations in brain function in women with breast cancer
TLDR
Functional magnetic resonance imaging in women before chemotherapy for localized breast cancer indicated compromised cognitive functioning before any chemotherapy and raise key questions for further research.
Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer
TLDR
Results indicate that high‐dose adjuvant chemotherapy is associated with long‐term cognitive impairments, underpinned by task‐specific hyporesponsiveness of dorsolateral prefrontal cortex and parahippocampal gyrus and a generalized hyporeSponsiveness of lateral posterior parietal cortex encompassing attentional processing.
Chemotherapy‐induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients
TLDR
It is shown that chemotherapy seems to affect WM integrity and that parameters derived from DTI have the required sensitivity to quantify neural changes related to chemotherapy‐induced mild cognitive impairment.
Adjuvant chemotherapy for breast cancer: effects on cerebral white matter seen in diffusion tensor imaging.
TLDR
The results of this pilot study suggest that adjuvant chemotherapy affects normal-appearing white matter in the genu of the corpus callosum and that this is related to the cognitive deficits experienced by patients.
Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5–10 years after chemotherapy
TLDR
Specific alterations in activity of frontal cortex, cerebellum, and basal ganglia in breast cancer survivors were documented by functional neuroimaging 5–10 years after completion of chemotherapy.
Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy.
TLDR
This case illustrates possible physiologic mechanisms that could produce long-term cognitive complaints among chemotherapy recipients and helps formulate hypotheses for further empirical study in the area of chemotherapy-associated cognitive dysfunction.
Cognitive adverse effects of chemotherapy in breast cancer patients
  • D. Correa, T. Ahles
  • Medicine, Psychology
    Current opinion in supportive and palliative care
  • 2007
TLDR
Significant advances have been made in the study of chemotherapy-related cognitive dysfunction over the past 10 years and studies using neuroimaging techniques and animal models have begun to examine structural and functional correlates of cognitive changes associated with chemotherapy.
Cognitive impairment associated with chemotherapy for breast cancer: An exploratory case-control study.
  • C. Booth, J. Vardy, I. Tannock
  • Medicine, Psychology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
TLDR
Self-reported cognitive impairment is associated with prior chemotherapy and changes in fMRI but not with formal cognitive testing, and as yet there is no significant correlation between symptoms and cytokine levels.
...
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2
3
4
5
...