Prebiotic metabolism: production by mineral photoelectrochemistry of alpha-ketocarboxylic acids in the reductive tricarboxylic acid cycle.


A reductive tricarboxylic acid (rTCA) cycle could have fixed carbon dioxide as biochemically useful energy-storage molecules on early Earth. Nonenzymatic chemical pathways for some steps of the rTCA cycle, however, such as the production of the alpha-ketocarboxylic acids pyruvate and alpha-ketoglutarate, remain a challenging problem for the viability of the… (More)
DOI: 10.1089/ast.2009.0356

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