Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA.

  title={Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA.},
  author={Eddy I. Jim{\'e}nez and Cl{\'e}mentine Gibard and Ramanarayanan Krishnamurthy},
  journal={Angewandte Chemie},
Recent demonstrations of RNA-DNA chimeras enabling RNA and DNA replication, coupled with prebiotic co-synthesis of deoxyribo- and ribo-nucleotides, have resurrected the hypothesis of co-emergence of RNA and DNA. As further support, we show that diamidophosphate (DAP) with 2-aminoimidazole (amido)phosphorylates and oligomerizes deoxynucleosides to form DNA - under conditions similar to those of ribonucleosides. The pyrimidine 5'-O-amidophosphates are formed in good (≈ 60%) yields. Intriguingly… Expand
2 Citations
2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
It is demonstrated that substitution of adenine with 2,6-diaminopurine enables repair of CPDs with yields reaching 92%. Expand
A physicochemical orthophosphate cycle via a kinetically stable thermodynamically activated intermediate enables mild prebiotic phosphorylations
The incorporation of orthophosphate from scarce geochemical sources into the organic compounds essential for life under mild conditions is a fundamental challenge for prebiotic chemistry and this system demonstrates a general strategy for how to maximise the usage of scarce resources based upon cycles which accumulate and then release activated intermediates. Expand