Prebiotic Peptides: Molecular Hubs in the Origin of Life.

  title={Prebiotic Peptides: Molecular Hubs in the Origin of Life.},
  author={Moran Frenkel-Pinter and Mousumi Samanta and Gonen Ashkenasy and Luke J. Leman},
  journal={Chemical reviews},
The fundamental roles that peptides and proteins play in today's biology makes it almost indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to extrapolate back from extant biology to the prebiotic world, one must acknowledge the critical importance that interconnected molecular networks, likely with peptides as key components, would have played in life's origin. In this review, we summarize chemical processes involving peptides that could have… 

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Nonenzymatic Metabolic Reactions and Life's Origins.

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Organic molecules are widely present in the dense interstellar medium, and many have been synthesized in the laboratory on Earth under the conditions typical for an interstellar environment. Until

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Peptide formation as on the early Earth: from amino acid mixtures to peptides in sulphur dioxide

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Modern mass spectrometry (MS)-based techniques were used to separate and sequence de novo proto-peptides containing broader combinations of prebiotically plausible monomers, revealing a high sequence diversity of plausible monomer combinations.

A model for the role of short self‐assembled peptides in the very early stages of the origin of life

  • Ohad CarnyE. Gazit
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2005
A novel mechanism for the origin of life that is based on the ability of short peptides to form encapsulated structures, catalyst chemical reaction, and serve as highly ordered template for the assembly of nucleotides is suggested.

Lipid-like self-assembling peptides.

A class of lipid-like peptides that have the potential to self-organize to form simple enclosures that stabilize other fragile molecules, to bring low concentration molecules into a local environment, and to enhance higher local concentration are discovered and designed.

Emergence of native peptide sequences in prebiotic replication networks

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Chemical pathways that could have brought about features of self-organization in a peptide world are considered in this review and discussed in relation with their possible contribution to the origin of life.

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Creating Prebiotic Sanctuary: Self-Assembling Supramolecular Peptide Structures Bind and Stabilize RNA

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