Prebiotic Adenine Revisited: Eutectics and Photochemistry

@article{Orgel2004PrebioticAR,
  title={Prebiotic Adenine Revisited: Eutectics and Photochemistry},
  author={Leslie E. Orgel},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={34},
  pages={361-369}
}
  • L. Orgel
  • Published 1 August 2004
  • Chemistry, Medicine
  • Origins of life and evolution of the biosphere
Recent studies support an earlier suggestion that, if adenine was formed prebiotically on the primitive earth, eutectic freezing of hydrogen cyanide solutions is likely to have been important. Here we revisit the suggestion that the synthesis of adenine may have involved the photochemical conversion of the tetramer of hydrogen cyanide in eutectic solution to 4-amino-5-cyano-imidazole. This would make possible a reaction sequence that does not require the presence of free ammonia. It is further… 
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Extraterrestrial nucleobases in the Murchison meteorite
Abstract Carbon-rich meteorites, carbonaceous chondrites, contain many biologically relevant organic molecules and delivered prebiotic material to the young Earth. We present compound-specific carbon
Adenine synthesis in interstellar space: mechanisms of prebiotic pyrimidine-ring formation of monocyclic HCN-pentamers.
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The mechanism for prebiotic pyrimidine-ring formation of monocyclic HCN-pentamers with ab initio electronic structure theory is studied, and the results primarily inform discussions of adenine synthesis in interstellar space.
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Laboratory synthesis of a large variety of important prebiotic molecules is surprisingly straightforward, using conditions likely to apply to the early Earth. The variety of compounds formed with a
A new route for the prebiotic synthesis of nucleobases and hydantoins in water/ice solutions involving the photochemistry of acetylene.
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A new explanation for the origin of hydantoins, purines, and pyrimidines in eutectic water/ice/urea solutions driven by ultraviolet irradiation of acetylene under anoxic conditions is reported.
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