Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study.

@article{Damjanovich1997PreassemblyOI,
  title={Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study.},
  author={S{\'a}ndor Damjanovich and L{\'a}szl{\'o} Bene and J{\'a}nos Matk{\'o} and A. Alileche and Carolyn K. Goldman and S Sharrow and Thomas A. Waldmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 24},
  pages={13134-9}
}
Assembly and mutual proximities of alpha, beta, and gamma(c) subunits of the interleukin 2 receptors (IL-2R) in plasma membranes of Kit 225 K6 T lymphoma cells were investigated by fluorescence resonance energy transfer (FRET) using fluorescein isothiocyanate- and Cy3-conjugated monoclonal antibodies (mAbs) that were directed against the IL-2R alpha, IL-2R beta, and gamma(c) subunits of IL-2R. The cell-surface distribution of subunits was analyzed at the nanometer scale (2-10 nm) by FRET on a… CONTINUE READING
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Damjanovich et al

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