Preantral ovarian follicles in serum-free culture: suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone.

@article{Mcgee1997PreantralOF,
  title={Preantral ovarian follicles in serum-free culture: suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone.},
  author={Elizabeth A. Mcgee and Norah Spears and Seigo Minami and Sheau Yu Hsu and Suk Young Chun and H{\aa}kan Billig and Aaron J. W. Hsueh},
  journal={Endocrinology},
  year={1997},
  volume={138 6},
  pages={
          2417-24
        }
}
Progression of preantral follicle development is essential to further follicle maturation and ovulation, but there are few models for studying the regulation of preantral follicle survival and growth. We have evaluated preantral follicle survival in vivo and in vitro, and have developed a serum-free rat follicle culture system that can be used to characterize the regulation of preantral follicle growth and differentiation. Analysis of ovarian cell DNA fragmentation during the first wave of… CONTINUE READING