Preanalytical factors and the measurement of cytokines in human subjects.

  title={Preanalytical factors and the measurement of cytokines in human subjects.},
  author={Benoit Dugu{\'e} and Esa A Lepp{\"a}nen and Ralph Gr{\"a}sbeck},
  journal={International journal of clinical & laboratory research},
  volume={26 2},
Cytokines are widely measured in research. However, cytokine analyses are influenced by a myriad of factors. For instance, a delay in the separation of plasma from cells may lead to a 50% decrease in the concentration of tumor necrosis factor in plasma. Another example is the secretion of interleukin-1 beta in women which can be twice as high during the follicular phase as in the luteal phase. The factors influencing the outcome of these tests can be divided into in vivo preanalytical factors… CONTINUE READING