Preadipocyte factor-1 is associated with metabolic profile in severe obesity.

  title={Preadipocyte factor-1 is associated with metabolic profile in severe obesity.},
  author={Jean O'Connell and Lydia Lynch and Andrew E. Hogan and Thomas J Cawood and Donal O'Shea},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={96 4},
CONTEXT Dysfunctional adipose tissue has been proposed as a key pathological process linking obesity and metabolic disease. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals. OBJECTIVE We hypothesized that adipose tissue from metabolically healthy obese (MHO) and matched metabolically unhealthy obese individuals… CONTINUE READING


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