Preactive lesions in multiple sclerosis

  title={Preactive lesions in multiple sclerosis},
  author={Paul Van Der Valk and Sandra Amor},
  journal={Current Opinion in Neurology},
Purpose of reviewKnowledge of the early pathological changes observed in multiple sclerosis (MS) has advanced by implementation of many improved pathological, biochemical and imaging techniques. This review highlights the accumulating evidence for early pathological changes we term ‘preactive lesions’, characterized by clusters of activated microglia in otherwise normal-appearing white matter. Recent findingsCompelling evidence is accumulating for pathological changes in normal-appearing white… 
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Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
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Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions
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Chronic inflammation in multiple sclerosis — seeing what was always there
  • P. Matthews
  • Biology, Medicine
    Nature Reviews Neurology
  • 2019
How advanced imaging techniques are enabling in vivo visualization of chronic CNS inflammation in multiple sclerosis that has previously been identified in histopathological studies is considered.
Anatomical Distribution of Cuprizone-Induced Lesions in C57BL6 Mice
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Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis
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