Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals.

@article{Pinyayev2011PreabsorptiveMO,
  title={Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals.},
  author={Tatyana S Pinyayev and Michael J Kohan and Karen M Herbin-Davis and John T. Creed and David J Thomas},
  journal={Chemical research in toxicology},
  year={2011},
  volume={24 4},
  pages={475-7}
}
The conventional scheme for arsenic methylation accounts for methylated oxyarsenical production but not for thioarsenical formation. Here, we report that in vitro anaerobic microbiota of mouse cecum converts arsenate into oxy- and thio- arsenicals. Besides methylarsonic acid (MMA(V)), arsenate was transformed into six unique metabolites: mono-, di-, and trithio-arsenic acid, monomethyldithio- and monomethyltrithio-arsonic acid, and dimethyldithioarsonic acid. Thioarsenicals were found in… CONTINUE READING

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