Pre vivo, ex vivo and in vivo evaluations of [68Ga]-EDTMP.

  title={Pre vivo, ex vivo and in vivo evaluations of [68Ga]-EDTMP.},
  author={Markus Mitterhauser and Stefan Toegel and Wolfgang Wadsak and Rupert Lanzenberger and Leonhard-Key Mien and Claudia Kuntner and Thomas Wanek and Harald Eidherr and Dagmar E. Ettlinger and Helmut Viernstein and Rainer Kluger and Robert Dudczak and Kurt Kletter},
  journal={Nuclear medicine and biology},
  volume={34 4},
INTRODUCTION The objectives of this study were to develop a simple preparation method for [68Ga]-EDTMP and to evaluate the applicability of [68Ga]-EDTMP as a potential positron emission tomography (PET) bone imaging agent using pre vivo, ex vivo and in vivo models. METHODS [68Ga]-EDTMP was prepared using 68Ga]-gallium chloride eluted from the 68Ge/68Ga generator and commercially available Multibone kits. Binding affinity to bone compartments was evaluated using a recently established pre vivo… CONTINUE READING
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