Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

@article{Ashabi2014PretreatmentWM,
  title={Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia},
  author={Ghorbangol Ashabi and Leila Khalaj and Fariba Khodagholi and Mahdi Goudarzvand and Alireza Sarkaki},
  journal={Metabolic Brain Disease},
  year={2014},
  volume={30},
  pages={747-754}
}
Global cerebral ischemia arises in patients who have a variety of clinical conditions including cardiac arrest, shock and asphyxia. In spite of advances in understanding of the brain ischemia and stroke etiology, therapeutic approaches to improve ischemic injury still remain limited. It has been established that metformin can attenuate cell death in cerebral ischemia. One of the main functions of metformin is proposed to be conducted via AMP-activated protein kinase (AMPK)-dependent pathway in… CONTINUE READING
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AMP - activated protein kinase counteracts brain - derived neurotrophic factorinduced mammalian target of rapamycin complex 1 signaling in neurons

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