Pre-treatment with intravenous granisetron to alleviate pain on propofol injection: A double-blind, randomized, controlled trial

@article{Ahmed2012PretreatmentWI,
  title={Pre-treatment with intravenous granisetron to alleviate pain on propofol injection: A double-blind, randomized, controlled trial},
  author={Ahsan Nazir Ahmed and Saikat Sengupta and Tanmoy Das and Amitava Rudra and Asif Iqbal},
  journal={Indian Journal of Anaesthesia},
  year={2012},
  volume={56},
  pages={135 - 138}
}
Background: Propofol is one of the widely used intravenous (i.v.) anaesthetics, although pain on injection still remains a considerable concern for the anaesthesiologists. A number of techniques has been tried to minimize propofol-induced pain with variable results. Recently, a 5-HT3 antagonist, ondansetron pre-treatment, has been shown to reduce propofol-induced pain. The aim of our randomized, placebo-controlled, double-blinded study was to determine whether pre-treatment with intravenous… 

Tables from this paper

Pre-Treatment with Intravenous Granisetron to Alleviate Pain on Propofol Injection: A Double Blind Randomised Controlled Study Using Normal Saline as Control
TLDR
Granisetron pre-treatment decrease the heart rate, systolic and diastolic blood pressure and pain on injection of propofol with the added advantage of avoiding the administration of other drugs that may be undesirable in certain circumstances.
Gabapentin pretreatment for propofol and rocuronium injection pain: A randomized, double-blind, placebo-controlled study
TLDR
Premedication with 1200 mg gabapentin 2 hours before propofol and rocuronium injection reduced the incidence and severity of injection pain.
A comparative study of attenuation of propofol-induced pain by lignocaine, ondansetron, and ramosetron
TLDR
Pre-treatment with IV ramosetron 0.3 mg is equally effective as 0.5 mg/kg of 2% lignocaine in preventing propofol-induced pain and both were better than ondansetron.
Comparative Study on the Effectiveness of Granisetron and Metoclopramide for Reducing Propofol Injection Pain
TLDR
Intravenous Granisetron at a dose of 2mg was moreeffective than intravenous Metoclopramide at a doses of 10 mg along with manual occlusion for one minute in reducing Propofol injection pain when given before prop ofol injection.
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron
TLDR
Pretreatment with ramosetron 0.3 mg and lidocaine 40 mg are equally effective in preventing pain from propofol injection.
Amelioration of Pain on Injection of Propofol: A Comparison of Pretreatment with Granisetron Vs Lignocaine.
TLDR
Parenteral administration of granisetron can be considered to be superior to lignocaine as pre treatment medication for pain relief after propofol injection along with the advantage of its anti-emetic effect.
Comparison of intravenous granisetron and intravenous lignocaine to alleviate pain on propofol injection: A double blind, randomized, controlled trial
TLDR
Both IV granisetron (2 mg) and IV lignocaine (30 mg) are equally effective in allaying pain on propofol injection.
Comparison the Effect of Granisetron and Dexamethasone on Intravenous Propofol Pain
TLDR
Pretreatment with intravenous granisetron (1 mg) and dexamethasone (0.15 mg/kg) before injection of propofol is effective and safe in reducing the incidence and severity of pain due to prop ofol injection.
COMPARATIVE STUDY BETWEEN INTRAVENOUS RAMOSETRON AND DEXAMETHASONE AS PRE-TREATMENT TO ATTENUATE PAIN DURING INTRAVENOUS PROPOFOL INJECTION
TLDR
Pre-treatment with intravenous ramosetron and dexamethasone both lead to relief of pain on injection of IV propofol without any significant difference between their effects.
Does Granisetron Pretreatment Relieve Pain Due to Propofol Injection
TLDR
Pretreatment with lignocaine is more effective in relieving pain on propofol injection than granisetron, according to the response of the patients to the injection.
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