Pre-treatment with Pamidronate Improves Bone Mechanical Properties in Mdx Mice Treated with Glucocorticoids

@article{Chen2018PretreatmentWP,
  title={Pre-treatment with Pamidronate Improves Bone Mechanical Properties in Mdx Mice Treated with Glucocorticoids},
  author={Jinghan Jenny Chen and Amanda J. Yoon and Marc D. Grynpas and Jane Mitchell},
  journal={Calcified Tissue International},
  year={2018},
  volume={104},
  pages={182-192}
}
Duchenne muscular dystrophy (DMD) is an X-linked disease of progressive muscle deterioration and weakness. Patients with DMD have poor bone health which is partly due to treatment with glucocorticoids, a standard therapy to prolong muscle function that also induces bone loss. Bisphosphonates are used to treat adults at risk of glucocorticoid-induced osteoporosis but are not currently used in DMD patients until after they sustain fractures. In this study, C57BL/10ScSn-mdx mice, a commonly used… CONTINUE READING
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