Pre-transplant donor CD4− invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease

@article{Rubio2017PretransplantDC,
  title={Pre-transplant donor CD4− invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease},
  author={M Prado Talavera Rubio and Marie Bouilli{\'e} and Naim Bouazza and Tereza Coman and H{\'e}l{\`e}ne Tr{\'e}b{\'e}den-N{\`e}gre and Arcadio G{\'o}mez and F. Revelles Su{\'a}rez and David Sibon and A. Brignier and Etienne Paubelle and S Nguyen-Khoc and Marina Cavazzana and Olivier Lantz and Mohamad Mohty and Salk Urien and Olivier Hermine},
  journal={Leukemia},
  year={2017},
  volume={31},
  pages={903-912}
}
Clinically useful pre-transplant predictive factors of acute graft-versus-host-disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-SCT) are lacking. We prospectively analyzed HSC graft content in CD34+, NK, conventional T, regulatory T and invariant natural killer T (iNKT) cells in 117 adult patients before allo-SCT. Results were correlated with occurrence of aGVHD and relapse. In univariate analysis, iNKT cells were the only graft cell populations associated with… CONTINUE READING
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