Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learning.

@article{Boulougouris2009PresurgicalTA,
  title={Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learning.},
  author={Vasileios Boulougouris and Trevor W. Robbins},
  journal={Behavioural brain research},
  year={2009},
  volume={197 2},
  pages={469-75}
}
We recently reported that orbitofrontal cortical (OFC) lesions impaired reversal learning of an instrumental two-lever spatial discrimination task, a deficit manifested as increased perseveration on the pre-potent response. Here we examine whether exposure to reversal learning test pre-operatively may have a beneficial effect for future reversal learning of OFC-lesioned animals. Rats were trained on a novel instrumental two-lever spatial discrimination and reversal learning task, measuring both… CONTINUE READING

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