Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.

@article{Brown2011PresteadystateKA,
  title={Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.},
  author={Jessica Anne Brown and Lindsey R. Pack and Jason D. Fowler and Zucai Suo},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 1},
  pages={276-83}
}
Nucleoside reverse transcriptase inhibitors (NRTIs) are an important class of antiviral drugs used to manage infections by human immunodeficiency virus, which causes AIDS. Unfortunately, these drugs cause unwanted side effects, and the molecular basis of NRTI toxicity is not fully understood. Putative routes of NRTI toxicity include the inhibition of human… CONTINUE READING