Pre-operative predictive factors for intra-operative pathological lymph node metastasis in rectal cancers.

  title={Pre-operative predictive factors for intra-operative pathological lymph node metastasis in rectal cancers.},
  author={Chun Gao and Jingtao Li and Long Fang and S. Wen and L. Zhang and Hong-chuan Zhao},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={14 11},
BACKGROUND A number of clinicopathologic factors have been found to be associated with pathological lymph node metastasis (pLNM) in rectal cancer; however, most of them can only be identified by expensive high resolution imaging or obtained after surgical treatment. Just like the Child-Turcotte-Pugh (CTP) and the model for end-stage liver disease (MELD) scores which have been widely used in clinical practice, our study was designed to assess the pre-operative factors which could be obtained… Expand
Lymph node ratio is an independent prognostic factor in node positive rectal cancer patients treated with preoperative chemoradiotherapy followed by curative resection.
LNR is an independent prognostic factor in ypN-positive rectal cancer patients, both in patients with <12 harvested LNs, and as well as in those ≥ 12 harvested LNSA, and provides better prognostic value than pN staging. Expand
Lymph Node Ratio as a Prognostic Factor in Rectal Cancer Cases with Preoperative Chemoradiotherapy and Curative Resection
The number of metastatic lymph nodes (LNs) has been demonstrated to be one of the most important prognostic factors in colorectal cancer (Greene et al., 2002). However, the number of metastatic LNsExpand
Significance and prognostic value of increased serum direct bilirubin level for lymph node metastasis in Chinese rectal cancer patients.
Higher serum direct bilirubin concentration was associated with the increased risk of LNM and poor prognosis in the rectal cancers in Chinese rectal cancer patients. Expand
Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China
Lymph node metastasis is an independent prognostic factor for OS in patients with T1-stage CRC and preoperative serum CA724, vascular invasion, and degree of differentiation are independent risk factors for lymph nodes metastasis. Expand
A logistic model including risk factors for lymph node metastasis can improve the accuracy of magnetic resonance imaging diagnosis of rectal cancer.
A logistic model including risk factors for lymph node metastasis can improve the accuracy of MRI diagnosis of rectal cancer. Expand
Accuracy of magnetic resonance imaging in pretreatment lymph node assessment for gynecological malignancies.
MRI should be used as a modality of choice in the pretreatment assessment of lymph nodes in proven gynaecological malignancies in order to determine the line of patient management, distinguishing surgical from non-surgical cases. Expand
Advantages of laparoscopic abdominoperineal resection for anastomotic recurrence of rectal cancer.
Laparoscopic abdomino-perineal resection is safe and feasible for anastomotic recurrence of rectal cancer. Expand
Seniors have a better learning curve for laparoscopic colorectal cancer resection.
Seniors could perform Laparoscopic colorectal resection with relatively better oncological outcomes and quicker recovery, and seniors could master the laparoscopic skill more easily and quickly. Expand


Venous invasion may predict lymph node metastasis in early rectal cancer.
  • S. Bayar, R. Saxena, B. Emir, R. Salem
  • Medicine
  • European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2002
The presence of venous invasion in early rectal cancer may provide valuable information to determine which patients would benefit from radical surgery, or adjuvant radiation therapy after sphincter-sparing surgery owing to an increased risk of lymph node metastasis. Expand
Predicting lymph node metastases in early rectal cancer.
Using the risk stratification-model, with the concept of local excision as a macro-biopsy with standby for subsequent immediate radical resection surgery in high-risk cases, could benefit patients by providing the advantages ofLocal excision yet ensuring adequate oncologic outcome. Expand
Improvement of staging by combining tumor and treatment parameters: the value for prognostication in rectal cancer.
NCRM staging of rectal cancer results in a broad range of survival rates and favorable patient grouping and gives strong evidence that a staging system combing tumor- and treatment-related factors provides better prognostic information than the classic TNM system, which is based solely on tumor- related factors. Expand
Depth of Tumor Invasion Independently Predicts Lymph Node Metastasis in T2 Rectal Cancer
Depth of invasion is an independent predictor for LNM in T2 rectal cancer in a subset of patients with low risk of LNM who may be candidates of local excision. Expand
Risk Factors for Lymph Node Metastasis in pT1 and pT2 Rectal Cancer: A Single-Institute Experience in 943 Patients and Literature Review
LVI, PD, and pT2 are independent risk factors predicting LNM in pT1–2 rectal carcinoma, and lymphovascular invasion and depth of invasion were significantly related to nodal involvement. Expand
Risk factors of lateral pelvic lymph node metastasis in advanced rectal cancer
Multivariate analysis showed that LPLN status diagnosed by CT, pathological regional lymph node status, tumor location, and tumor differentiation were significant risk factors for LPLn metastasis. Expand
Impact of number of nodes retrieved on outcome in patients with rectal cancer.
The results suggest that the pathologic assessment of lymph nodes in surgical specimens is often inaccurate and that examining greater number of nodes increases the likelihood of proper staging, and that some patients who might benefit from adjuvant therapy are misclassified as node-negative due to incomplete sampling of lymph node. Expand
Chromosomal Copy Number Alterations Are Associated with Persistent Lymph Node Metastasis After Chemoradiation in Locally Advanced Rectal Cancer
Copy number alterations can help identify patients with rectal cancer who are at risk of lymph node metastasis after chemoradiation and the accuracy of oligonucleotide array-based comparative genomic hybridization for predicting lymph nodes metastasis is assessed. Expand
Imaging for predicting the risk factors--the circumferential resection margin and nodal disease--of local recurrence in rectal cancer: a meta-analysis.
A meta-analysis of English literature on the accuracy of preoperative imaging in predicting the two most important risk factors for local recurrence in rectal cancer, the circumferential resection margin (CRM) and the nodal status (N-status) shows that MRI is rather accurate in diagnosing a close or involved CRM. Expand
Population-based analyses of lymph node metastases in colorectal cancer.
Even patients with superficial CRCs have a significant risk of nodal metastases, and this risk should be considered when balancing the risks and benefits of minimally invasive techniques such as local excision or endoscopic resection for the treatment of CRC. Expand