Pre-operative Differentiation of Pediatric Ovarian Tumors: Morphological Scoring System and Tumor Markers

  title={Pre-operative Differentiation of Pediatric Ovarian Tumors: Morphological Scoring System and Tumor Markers},
  author={Zoran B. Stankovi{\'c} and Milan K Djuki{\'c} and Djordje Savic and Branislav Luk{\'a}{\vc} and Slavisa M. Djuricic and Katarina Sedlecki and Danilo Zdravkovi{\'c}},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  pages={1231 - 1238}
OBJECTIVE To investigate the importance of morphological scoring systems in differentiation of ovarian tumors in childhood. METHODS Morphological assessment using DePriest's index was performed for all patients with histopathological confirmation of ovarian tumor, with evaluation of tumor markers, from January 1997. RESULTS Fifty-three girls (age range 13 months to 19 years) were surgically treated for 59 ovarian tumors, including six bilateral. All lesions with cystic appearance on… 

Figures and Tables from this paper

Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors

The novel pediatric risk-of-malignancy index is able to accurately discriminate between benign and non-benign ovarian tumors in children and adolescents and may guide surgical management decisions before the availability of histological confirmation.

The Role of Tumor Markers in the Surgical Approach of Ovarian Masses in Pediatric Age: A 10-Year Study and a Literature Review

The role of tumor markers in the differential diagnosis and in the choice of the surgical treatment of ovarian lesions in pediatric age is detected, and caution is suggested to optimize future fertility.

Torsion of Malignant Ovarian Tumors in Childhood and Adolescence

The most common torsioned malignant ovarian tumors were of germ cell origin, in both premenarchal and post menarchal girls, and it is nevertheless possible at any stage of disease.

Ovarian masses in pediatric patients: a multicenter study of 98 surgical cases in Tunisia

  • I. AbidM. Zouari R. Mhiri
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2018
In this study, a multicentric Tunisian study concerning the clinical practice and the management of pediatric ovarian masses and the factors that are associated with ovarian preservation are reported to recommend that surgical management of ovarian masses in children should be based on ovarian-preserving surgery.

The Correlation of Ovarian Masses and Risk of Oophorectomy in Pediatric Patients

In the present study, the risk factors for oophorectomy were a malignant pathology and large tumor size and it is recommended that surgical management of ovarian masses in children should be based on ovarian preserving surgery.

Functional ovarian lesions in children and adolescents: when to remove them

In pediatric subjects, functional ovarian cysts rarely required surgical intervention, though no complications or disorder recurrence were reported, and conservative surgery has to be performed whenever feasible to preserve ovarian function.

Diagnostic, Prognostic and Predictive Markers in Pediatric Germ Cell Tumors—Past, Present and Future

The aim of the review was to present the role of serum tumor markers in the clinical staging, treatment monitoring and follow-up of pediatric patients with GCTs and show new possibilities.



A morphology index based on sonographic findings in ovarian cancer.

The findings of the present investigation indicate that the morphology index is a cost effective adjuvant method which significantly increases the specificity and positive predictive value of transvaginal sonography.

Ovarian Lesions in Children and Adolescents - An 11-year Review

Physiological or functional ovarian cysts are the most common ovarian lesions seen in the pediatric age group and malignant neoplasms are rare and a palpable abdominal mass or ovarian lesion >10 cm was significantly associated with the lesion being neoplastic.

Accuracy of intraoperative frozen section diagnosis of ovarian tumors.

Frozen section diagnosis seems to be a reliable method for ovarian tumors, with high sensitivity for malignant neoplasms and a low false-positive rate which allow the best choice of treatment.

Surgery for ovarian masses in infants, children, and adolescents: 102 consecutive patients treated in a 15-year period.

Ovarian pathology remains a rare indication for surgery in girls less than 20 years of age because most of these lesions are benign, ovarian-preserving operations should be performed whenever feasible.

Ovarian tumors during childhood and adolescence. A clinicopathological study.

Ovarian tumors during the first two decades of life represent the most frequent tumors of the female genital tract at this age. Clinical and therapeutical particularities differentiate them from the

Doppler flow and arterial location in ovarian tumors

Immature ovarian teratoma in an adolescent: a case report and review of the literature.

The role of CA 125 in clinical practice

A retrospective case note audit looking at patients who had a CA125 measurement performed between April 2000 and April 2002 confirmed the high false positive rate and poor sensitivity and specificity associated with CA125.

Pediatric ovarian tumors: A review of 67 cases

Ovarian tumors are uncommon but important childhood neoplasms and are an important cause of cancer in women.