Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Abstract

Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These “non-metastatic” exosomes stimulate an innate immune response through the expansion of Ly6Clow patrolling… (More)
DOI: 10.1038/s41467-017-01433-3

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