Pre-melting dynamics of DNA and its relation to specific functions.

  title={Pre-melting dynamics of DNA and its relation to specific functions.},
  author={Boian S. Alexandrov and Nikolaos K. Voulgarakis and Kim O. Rasmussen and Anny Usheva and A. R. Bishop},
  journal={Journal of physics. Condensed matter : an Institute of Physics journal},
  volume={21 3},
We discuss connections between the nonlinear dynamics of double-stranded DNA, experimental findings, and specific DNA functions. We begin by discussing how thermally induced localized openings (bubbles) of the DNA double strand are important for interpreting dynamic force spectroscopy data. Then we demonstrate a correlation between a sequence-dependent propensity for pre-melting bubble formation and transcription initiation and other regulatory effects in viral DNA. Finally, we discuss the… CONTINUE READING