Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity.

@article{Mayer2005PremRNATF,
  title={Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity.},
  author={M{\'a}rio Gustavo Mayer and Lucile Maria Floeter-Winter},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2005},
  volume={100 5},
  pages={501-13}
}
Since the discovery that genes are split into intron and exons, the studies of the mechanisms involved in splicing pointed to presence of consensus signals in an attempt to generalize the process for all living cells. However, as discussed in the present review, splicing is a theme full of variations. The trans-splicing of pre-mRNAs, the joining of exons from distinct transcripts, is one of these variations with broad distribution in the phylogenetic tree. The biological meaning of this… CONTINUE READING

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