Pre-irradiation internal carotid artery BCNU in treatment of glioblastoma multiforme.

  title={Pre-irradiation internal carotid artery BCNU in treatment of glioblastoma multiforme.},
  author={Robina Bashir and Fred H Hochberg and Rita M. Linggood and K Hottleman},
  journal={Journal of neurosurgery},
  volume={68 6},
High-dose 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) infusion into the internal carotid artery following cranial irradiation in the treatment of glioblastoma multiforme is accompanied by evidence of leukoencephalopathy in a significant number of patients. In an attempt to avoid this problem, a phase I trial was performed using intracarotid BCNU infusion before irradiation. Twenty-eight patients with grade III/III astrocytoma (World Health Organization Classification, equivalent to Kernohan… CONTINUE READING


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