Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction following Re-Administration in Rat Brain

@inproceedings{Yang2013PreimmunizationWA,
  title={Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction following Re-Administration in Rat Brain},
  author={Chun Yang and Wei-hua Yang and Sha-Sha Chen and Bao-Feng Ma and Bin Li and Tao Lu and T Qu and Ronald L. Klein and Li-Ru Zhao and wei-Ming Duan},
  booktitle={PloS one},
  year={2013}
}
We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO transduction in rat brain. We first characterized transgene expression and immune responses against… CONTINUE READING
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