Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine.

@article{Stevens2005PreexistingIT,
  title={Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine.},
  author={Rosemary Winifred Stevens and Alora Lavoy and Shila K. Nordone and Maryjo Burkhard and Gregg A Dean},
  journal={Vaccine},
  year={2005},
  volume={23 12},
  pages={
          1479-90
        }
}
Listeria monocytogenes is an attractive biologic vaccine vector against HIV because it induces a strong cell mediated immune response, can be delivered by mucosal routes, can be readily manipulated to express viral antigens, and is easy and inexpensive to produce. Proof of concept studies have been performed using HIV Gag expressing recombinant L. monocytogenes in the mouse. Here we report the development and validation of recombinant L. monocytogenes to be evaluated in the FIV/cat model of HIV… CONTINUE READING
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