Pre-existing immunity against vaccine vectors – friend or foe?

  title={Pre-existing immunity against vaccine vectors – friend or foe?},
  author={Manvendra Saxena and Thi Thu Hao Van and Fiona J. Baird and Peter J. Coloe and Peter M Smooker},
Over the last century, the successful attenuation of multiple bacterial and viral pathogens has led to an effective, robust and safe form of vaccination. Recently, these vaccines have been evaluated as delivery vectors for heterologous antigens, as a means of simultaneous vaccination against two pathogens. The general consensus from published studies is that these vaccine vectors have the potential to be both safe and efficacious. However, some of the commonly employed vectors, for example… CONTINUE READING

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for biodefence

  • S. R. Attridge, R. Davies, J. T. LaBrooy
  • 1997
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