Pre-existing Antibody: Biotherapeutic Modality-Based Review

@article{Gorovits2016PreexistingAB,
  title={Pre-existing Antibody: Biotherapeutic Modality-Based Review},
  author={Boris Gorovits and Adrienne Clements-Egan and M. A. Birchler and Meina Liang and Heather A Myler and Kun Peng and Shobha Purushothama and Manoj Rajadhyaksha and Laura Salazar-Fontana and Crystal Sung and Li Qiong Xue},
  journal={The AAPS Journal},
  year={2016},
  volume={18},
  pages={311-320}
}
Pre-existing antibodies to biotherapeutic drugs have been detected in drug-naïve subjects for a variety of biotherapeutic modalities. Pre-existing antibodies are immunoglobulins that are either specific or cross-reacting with a protein or glycan epitopes on a biotherapeutic compound. Although the exact cause for pre-existing antibodies is often unknown, environmental exposures to non-human proteins, glycans, and structurally similar products are frequently proposed as factors. Clinical… CONTINUE READING
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