Pre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.

@article{Baron2002PreemptiveIW,
  title={Pre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.},
  author={Fr{\'e}d{\'e}ric Baron and Jean Siquet and Nicole Schaaf-Lafontaine and Etienne Baudoux and Jean-Philippe Hermanne and Georges Fillet and Yves Beguin},
  journal={Haematologica},
  year={2002},
  volume={87 1},
  pages={78-88}
}
BACKGROUND AND OBJECTIVES To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60… CONTINUE READING
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Nonmyeloablative stem cell transplantation ( NMSCT ) with CD 8 - depleted or CD 34 - selected PBSC

  • F Baron, E Baudoux, P Frère
  • J Hematother Stem Cell Res
  • 2001

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