Pre-ejection period reactivity and psychiatric comorbidity prospectively predict substance use initiation among middle-schoolers: a pilot study.

@article{Brenner2011PreejectionPR,
  title={Pre-ejection period reactivity and psychiatric comorbidity prospectively predict substance use initiation among middle-schoolers: a pilot study.},
  author={Sharon L. Brenner and Theodore P Beauchaine},
  journal={Psychophysiology},
  year={2011},
  volume={48 11},
  pages={
          1588-1596
        }
}
Youth with conduct problems (CPs) or depression are at high risk for early initiation of substance use, and for future substance use disorders (SUDs). Comorbid CPs and depression increase risk even further, yet understanding how these conditions interact remains elusive. One hypothesis is that altered mesolimbic dopamine function contributes to symptoms of CPs, depression, and SUDs. Cardiac pre-ejection period (PEP) reactivity to incentives is linked theoretically and functionally to central… CONTINUE READING
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