Pre-eclampsia

@article{Steegers2010Preeclampsia,
  title={Pre-eclampsia},
  author={Eric A. P. Steegers and Peter von Dadelszen and Johannes J Duvekot and Robert Pijnenborg},
  journal={The Lancet},
  year={2010},
  volume={376},
  pages={631-644}
}
Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features. Poor early placentation is especially associated with early onset disease. Predisposing cardiovascular or metabolic risks for endothelial dysfunction, as part of an exaggerated systemic inflammatory response, might… 
DIFFERENTIATED APPROACH TO RISK ASSESSMENT OF DEVELOPING PLACENTA-ASSOCIATED COMPLICATIONS IN PREGNANT WOMAN WITH PREECLAMPSIA
TLDR
It has been shown that the markers of the propensity to develop obstetric and perinatal complications in pregnant women with preeclampsia are the following gene polymorphisms: 1691 GA in gene factor V Leiden and 20210 AA in prothrombin gene, which are associated with severe pre-eClampsia, early onset and development of life-threatening maternal and fetal complications.
Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
TLDR
The PHOENIX trial aims to address the uncertainty for women where the balance of benefits and risks of delivery compared to expectant management are uncertain and to influence clinical practice internationally, through direct adoption and by incorporation into guidelines in countries with similar settings.
Placental morphology and the prediction of underlying cardiovascular risk factors.
TLDR
The findings of the current study identify clinical measurements that can be collected at the time of delivery which may help identify specific women who may benefit most from postpartum cardiovascular risk screening and intervention.
Increased proteinuria and uric acid levels are associated with eclamptic crisis.
TLDR
The data suggest that the combination of high levels of maternal serum uric acid and proteinuria are strongly associated with the development of eclamptic crises.
Eculizumab Treatment for Postpartum HELLP Syndrome and aHUS—Case Report
TLDR
Earlier initiation of eculizumab treatment may potentially shorten and mitigate the disease and hypothetically decrease future health risks of preeclamptic women.
Planned early delivery versus expectant management to reduce adverse pregnancy outcomes in pre-eclampsia in a low- and middle-income setting: study protocol for a randomised controlled trial (CRADLE-4 Trial)
TLDR
The CRADLE-4 Trial is the first trial evaluating the optimal timing of delivery in pre-eclampsia in LMIC, where resources and disease burden are considerably different and the balance of risks and benefits needs to be carefully assessed.
Acute Cardiac Effects of Severe Pre-Eclampsia.
TLDR
Women with PEC have higher RVSP, higher rates of abnormal diastolic function, decreased global RVLSS, increased left-sided chamber remodeling, andHigher rates of peripartum pulmonary edema, when compared with healthy pregnant women.
Renal complications during pregnancy: In the hypertension spectrum.
TLDR
The hemodynamic and vascular changes, anatomical and physiologic renal adaptations occurring during normal pregnancy and the complications which arise in the setting of hypertensive diseases are discussed.
Epidemiology and maternal prognosis of hypertension disorders of pregnancy in French Guiana.
TLDR
The study shows a high prevalence of PE in patients with HDP, and hospitalization and repeated clinical evaluation are needed to screen for women exposed to develop PE or severe PE.
Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia.
TLDR
This approach highlights the different pathways that are involved in the vascular regulation of the human placenta, changes that occur during PE and the importance of focusing on restoring these dysfunctional systems when studying treatment strategies for PE.
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References

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TLDR
Current evidence on management of pre-eclampsia is summarized, which includes identification and referral of women at high risk, prompt diagnosis with prevention and treatment of complications, and timely delivery (the only definitive cure).
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TLDR
It may be the acuity of the blood pressure rise in the setting of endothelial dysfunction that interrupts the delicate balance between capillary and cellular perfusion pressures that leads to the neurological complications of pre-eclampsia.
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TLDR
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TLDR
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TLDR
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TLDR
Although it is a low cost effective treatment, magnesium sulfate is not available in all low and middle income countries; scaling up its use for eClampsia and severe preeclampsia will contribute to achieving the Millennium Development Goals.
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TLDR
Antiplatelet agents during pregnancy are associated with moderate but consistent reductions in the relative risk of pre-eclampsia, of birth before 34 weeks' gestation, and of having a pregnancy with a serious adverse outcome.
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TLDR
There is insufficient evidence to determine whether adjunctive steroid use in HELLP syndrome decreases maternal and perinatal mortality, major maternal andperinatal morbidity.
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