Pre-dispositions and epigenetic inheritance in the Escherichia coli lactose operon bistable switch

@inproceedings{Robert2010PredispositionsAE,
  title={Pre-dispositions and epigenetic inheritance in the Escherichia coli lactose operon bistable switch},
  author={L Replogle Robert and Gregory Paul and Yong Chen and François Taddei and Damien Baigl and Ariel B. Lindner},
  booktitle={Molecular systems biology},
  year={2010}
}
The lactose operon regulation in Escherichia coli is a primary model of phenotypic switching, reminiscent of cell fate determination in higher organisms. Under conditions of bistability, an isogenic cell population partitions into two subpopulations, with the operon's genes turned on or remaining off. It is generally hypothesized that the final state of a cell depends solely on stochastic fluctuations of the network's protein concentrations, particularly on bursts of lactose permease expression… CONTINUE READING