Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

@article{Dean2004PrediabetesIT,
  title={Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells},
  author={B. Dean and R. Walker and A. Bone and J. Baird and A. Cooke},
  journal={Diabetologia},
  year={2004},
  volume={28},
  pages={464-466}
}
  • B. Dean, R. Walker, +2 authors A. Cooke
  • Published 2004
  • Biology, Medicine
  • Diabetologia
  • SummaryUse of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on vascular endothelium and this precedes lymphocytic infiltration. Next, T cells of the T helper phenotype infiltrate the pancreas around blood vessels. Many of the infiltrating… CONTINUE READING
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