Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

@article{Dean1985PrediabetesIT,
  title={Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells},
  author={Betty Dean and Russell Walker and Adrian J. Bone and Joyce D. Baird and Anne Cooke},
  journal={Diabetologia},
  year={1985},
  volume={28},
  pages={464-466}
}

• Betty Dean, Russell Walker, +2 authors Anne Cooke
• Published 1985 in Diabetologia
• DOI:10.1007/BF00280892

Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on vascular endothelium and this precedes lymphocytic infiltration. Next, T cells of the T helper phenotype infiltrate the pancreas around blood vessels. Many of the infiltrating T… CONTINUE READING

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