Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

@article{Dean1985PrediabetesIT,
  title={Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells},
  author={Betty Dean and Russell Walker and Adrian J. Bone and Joyce D. Baird and Anne Cooke},
  journal={Diabetologia},
  year={1985},
  volume={28},
  pages={464-466}
}
Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on vascular endothelium and this precedes lymphocytic infiltration. Next, T cells of the T helper phenotype infiltrate the pancreas around blood vessels. Many of the infiltrating T… CONTINUE READING
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Development of diabetes in the BB/E rat: parietal cell, smooth muscle, thyroid epithelium, islet cell surface and cytoplasmic antibodies and fl-cell function

A JBone, R Walker, JD Baird, A Cooke
Diabetologia 27: • 1984
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Evidence of the expression of class II ( HLA - DR ) and increased presentation of class I ( HLA - A , B , C ) molecules in pancreatic islets in Type I ( insulin dependent ) diabe

GF Bottazzo, BM Dean
Diabetologia • 1984

Evidence of the expression of class II (HLA-DR) and increased presentation of class I (HLA-A, B, C) molecules in pancreatic islets in Type I (insulin dependent) diabetes

GF Bottazzo, BM Dean
Diabetologia 27: • 1984
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