Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

@inproceedings{Darby2019PreconceptionMH,
  title={Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring},
  author={Matthew Darby and Alisha Chetty and Dunja Mrjden and Marion Rolot and Katherine Ann Smith and Claire Mackowiak and Delphine Sedda and Donald D. Nyangahu and Heather B Jaspan and Kai-Michael Toellner and Ari Waisman and Val{\'e}rie F. J. Quesniaux and Bernhard Ryffel and Adam F Cunningham and Benjamin G Dewals and Frank Brombacher and William G Horsnell},
  booktitle={Science advances},
  year={2019}
}
Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was… CONTINUE READING

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