Corpus ID: 24369375

Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta)

@article{Kumar2013PreclinicalT,
  title={Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta)},
  author={B. D. Kumar and P. U. Kumar and T. P. Krishna and S. Kalyanasundaram and P. Suresh and V. Jagadeesan and S. Hariharan and A. Naidu and K. Krishnaswamy and P. N. Rangarajan and V. Srinivasan and G. N. Reddy and B. Sesikeran},
  journal={The Indian Journal of Medical Research},
  year={2013},
  volume={137},
  pages={1072 - 1088}
}
  • B. D. Kumar, P. U. Kumar, +10 authors B. Sesikeran
  • Published 2013
  • Biology, Medicine
  • The Indian Journal of Medical Research
  • Background & objectives: Pre-clinical toxicology evaluation of biotechnology products is a challenge to the toxicologist. The present investigation is an attempt to evaluate the safety profile of the first indigenously developed recombinant DNA anti-rabies vaccine [DRV (100 μg)] and combination rabies vaccine [CRV (100 μg DRV and 1.25 IU of cell culture-derived inactivated rabies virus vaccine)], which are intended for clinical use by intramuscular route in Rhesus monkeys. Methods: As per the… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    DNA immunization protects nonhuman primates against rabies virus
    • 136
    DNA Vaccines: Developing New Strategies against Cancer
    • 169
    • PDF
    Subacute toxicity of adsorbed 250 Lf tetanus toxoid in rats.
    • 2