Pre-clinical studies of pramipexole: clinical relevance.

  title={Pre-clinical studies of pramipexole: clinical relevance.},
  author={Jean Pintar Hubble},
  journal={European journal of neurology},
  volume={7 Suppl 1},
This paper reviews the preclinical study of the novel dopamine agonist pramipexole and its use in early Parkinson's disease (PD). Emphasis will be given to those properties distinguishing this drug from other dopamine agonists, the relevance of the preclinical data to clinical trial results in early PD, and the putative neuroprotective properties of the compound. The conventional dopamine agonists are ergot-derived compounds that are most widely used as adjunctive therapies in advancing… CONTINUE READING
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