Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate

@inproceedings{Brennan2013PreclinicalSO,
  title={Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate},
  author={Meadhbh {\'A}ine Brennan and Audrey Renaud and J{\'e}r{\^o}me Amiaud and Markus Thomas Rojewski and Hubert Schrezenmeier and DavidL. Heymann and Val{\'e}rie Trichet and Pierre Layrolle},
  booktitle={Stem Cell Research & Therapy},
  year={2013}
}
IntroductionRepair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential for bone regeneration. However, their isolation, expansion and implantation will need to be conducted under good manufacturing practices (GMP) at separate locations. An investigation which mimics this clinical scenario where large bone defects shall be regenerated is required… CONTINUE READING
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