Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity

@article{Sadi2008PreclinicalDA,
  title={Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity},
  author={H. Sa{\"i}di and M. Jenabian and B. Gombert and C. Charpentier and A. Mannarini and L. B{\'e}lec},
  journal={AIDS Research and Therapy},
  year={2008},
  volume={5},
  pages={10 - 10}
}
BackgroundTerpenoid derivatives originating from many plants species, are interesting compounds with numerous biological effects, such as anti-HIV-1 activity. The zinc tetra-ascorbo-camphorate complex (or "C14"), a new monoterpenoid derivative was evaluated in vitro for its anti-HIV-1 activity on both R5- and X4-HIV-1 infection of primary target cells (macrophages, dendritic cells and T cells) and on HIV-1 transfer from dendritic cells to T cells.ResultsThe toxicity study was carried out in… Expand
In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).
Partial inactivation of CCR5- and CXCR4- tropic HIV-1 by human urine
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References

SHOWING 1-10 OF 33 REFERENCES
Preclinical Evaluation of Synthetic −2 RANTES as a Candidate Vaginal Microbicide To Target CCR5
Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
  • Robert H. Cichewicz, Samir A. Kouzi
  • Chemistry, Medicine
  • Medicinal research reviews
  • 2004
IN VITRO INACTIVATION OF HIV-1 BY CONTRACEPTIVE SPONGE CONTAINING NONOXYNOL-9
Intravaginal toxicity studies of a gel-microemulsion formulation of spermicidal vanadocenes in rabbits.
Pharmacological properties of the ubiquitous natural product betulin.
Elimination of metabolic cooperation by glycyrrhetinic acid, an anti-tumor promoter, in cultured Chinese hamster cells.
Molecular targets of anti-HIV-1 triterpenes.
...
1
2
3
4
...