Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria.

@article{Abubakar2010PreclinicalAP,
  title={Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria.},
  author={Saidu Bello Abubakar and Isa Sadeeq Abubakar and Abdulrazaq G Habib and Abdusalami Nasidi and Nandul Durfa and Peter Ofemile Yusuf and Solomon Larnyang and John M Garnvwa and Elijah Sokomba and Lateef Salako and G Laing and Robert David Geoffrey Theakston and Ed Juszczak and Nicola C. Alder and David A. Warrell},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2010},
  volume={55 4},
  pages={719-23}
}
The aim of this study was to identify candidate antivenoms with specific activity against the venom of the saw-scaled or carpet viper (Echis ocellatus) in northern Nigeria, where bites by this species cause great morbidity and mortality but where effective antivenoms have become scarce and unaffordable. Selected antivenoms were destined to be compared by randomised controlled clinical trials (RCTs). Standard pre-clinical neutralisation assays were carried out in rodents. We included two… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Snakebite envenoming

Nature Reviews Disease Primers • 2017

Similar Papers

Loading similar papers…