Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.

@article{Tyler2007PreassemblyOS,
  title={Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.},
  author={Douglas R. Tyler and Meredith E. Persky and Loderick A. Matthews and Sheuwen Chan and Joshua D Farrar},
  journal={Molecular immunology},
  year={2007},
  volume={44 8},
  pages={1864-72}
}
CD4(+) T cells regulate adaptive responses to pathogens by secreting unique subsets of cytokines that mediate inflammatory processes. The innate cytokines IL-12 and IFN-alpha/beta regulate type I responses and promote acute IFN-gamma secretion through the activation of the STAT4 transcription factor. Although IL-12-induced STAT4 activation is a conserved pathway across species, IFN-alpha/beta-dependent STAT4 phosphorylation does not occur as efficiently in mice as it does in human T cells. In… CONTINUE READING

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