Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia.

  title={Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia.},
  author={Erik H. Niks and Jan B M Kuks and John H. J. Wokke and Henk Veldman and Egbert Bakker and Jan J G M Verschuuren and Jaap J. Plomp},
  journal={Muscle & nerve},
  volume={42 2},
Autoantibodies to muscle-specific kinase (MuSK) can cause myasthenia gravis (MG). The pathophysiological mechanism remains unknown. We report in vitro electrophysiological and histological studies of the neuromuscular junction in a MuSK MG patient. Low levels of presynaptic acetylcholine release and small miniature endplate potentials were found. This combination of pre- and postsynaptic abnormalities was supported by histology, revealing partially denervated postsynaptic areas, and some… CONTINUE READING


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