Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole.

Abstract

Riluzole is the sole treatment for amyotrophic lateral sclerosis (ALS), but its therapeutically relevant actions on motor neurons are not well defined. Whole cell patch-clamp recordings were made from hypoglossal motor neurons (HMs, n = 25) in brain stem slices from 10- to 23-day-old rats anesthetized with pentobarbital sodium to investigate the hypothesis… (More)
DOI: 10.1152/jn.00587.2012

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