Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses

@article{Berg2013PreAP,
  title={Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses},
  author={L. K. Berg and Max Larsson and Cecilie Morland and Vidar Gundersen},
  journal={Neuroscience},
  year={2013},
  volume={230},
  pages={139-150}
}

Figures and Tables from this paper

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses
TLDR
By increasing presynaptic calcium, preNMDARs fine tune mossy fiber neurotransmission and can control information transfer during dentate granule cell burst activity that normally occur in vivo.
Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses
TLDR
By increasing presynaptic calcium, preNMDARs fine-tune mossy fiber neurotransmission and can control information transfer during dentate granule cell burst activity that normally occur in vivo.
Neto Auxiliary Protein Interactions Regulate Kainate and NMDA Receptor Subunit Localization at Mossy Fiber–CA3 Pyramidal Cell Synapses
TLDR
It is confirmed that Neto protein interactions regulate synaptic localization of KAR and NMDAR subunits at MF–CA3 synapses, with implications for both ionotropic and metabotropic glutamatergic recruitment of the CA3 network.
Activity‐dependent control of NMDA receptor subunit composition at hippocampal mossy fibre synapses
CA3 pyramidal cells display input‐specific differences in the subunit composition of synaptic NMDA receptors (NMDARs). Although at low density, GluN2B contributes significantly to NMDAR‐mediated
Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases
TLDR
The findings confirm the existence of presynaptic GluN3A-containing release-regulating NMDARs in mouse hippocampal glutamatergic nerve endings and unveil presyaptic alteration of the Glu n subunit insertion in synaptosomal plasma membranes elicited by anti-GluN antibodies that might be relevant to the central alterations occurring in patients suffering from autoimmune anti-NMDA diseases.
Presynaptic NMDA receptors: Roles and rules
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus
TLDR
The role of extracellular proteolysis in various aspects of synaptic plasticity in hippocampal mossy fiber synapses is reviewed, and a growing body of evidence demonstrates that among perisynaptic proteases, tissue plasminogen activator (tPA)/plasmin system, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and metalloproteinases play a crucial role in shaping plastic changes in this projection.
...
1
2
3
...

References

SHOWING 1-10 OF 86 REFERENCES
Presynaptic changes during mossy fibre LTP revealed by NMDA receptor-mediated synaptic responses
ACTIVITY-DEPENDENT changes in synaptic strength are important for learning and memory. Long-term potentiation (LTP) of glutamatergic excitatory synapses following brief repetitive stimulation
GABA and GABAA receptors at hippocampal mossy fibre synapses
TLDR
Results provide further evidence for GABA and glutamate cotransmission at mossy fibre synapses, although paired pre‐ and post‐synaptic recordings will be required to determine the role of GABA at this unusual synapse.
Organization of Ionotropic Glutamate Receptors at Dendrodendritic Synapses in the Rat Olfactory Bulb
TLDR
The principles recently found to underlie the organization of glutamate receptors at axospinous synapses also apply to dendrodendritic synapses, and it is demonstrated that both NMDA and AMPA receptors are available for dendRodendritic signaling between mitral and granule cells.
Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre‐recipient layer) of the mouse hippocampal CA3 subfield
TLDR
The selective scarcity of theseNMDA receptor subunits in the stratum lucidum suggests that a different synaptic targeting mechanism exerts within a single CA3 pyramidal neurone in vivo, which would explain contrasting significance of the NMDA receptor channel in LTP induction mechanisms between the mossy fibre‐CA3 synapse and other hippocampal synapses.
Comparison of two forms of long-term potentiation in single hippocampal neurons.
TLDR
Although the induction of associational-commissural LTP requires in the postsynaptic cell N-methyl-D-aspartate (NMDA) receptor activation, membrane depolarization, and a rise in calcium, mossy fiber LTP does not.
Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats
TLDR
The results provide the cellular basis for NMDA receptors' participation in (1) postsynaptic membrane excitability, (2) regulation of transmitter release, (3) and, in the deeper laminae, astrocyte responses.
...
1
2
3
4
5
...