Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience.

@article{Gtherstrm2014PreAP,
  title={Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience.},
  author={Cecilia G{\"o}therstr{\"o}m and Magnus Westgren and S W Steven Shaw and Eva {\AA}str{\"o}m and Arijit Biswas and Peter H Byers and Citra Nurfarah Zaini Mattar and Gail E. Graham and Jahan Taslimi and Uwe W Ewald and Nicholas M Fisk and Allen Eng Juh Yeoh and Ju-Li Lin and Po-jen Cheng and Mahesh Choolani and Katarina le Blanc and J. K. Y. Chan},
  journal={Stem cells translational medicine},
  year={2014},
  volume={3 2},
  pages={255-64}
}
Osteogenesis imperfecta (OI) can be recognized prenatally with ultrasound. Transplantation of mesenchymal stem cells (MSCs) has the potential to ameliorate skeletal damage. We report the clinical course of two patients with OI who received prenatal human fetal MSC (hfMSC) transplantation and postnatal boosting with same-donor MSCs. We have previously reported on prenatal transplantation for OI type III. This patient was retransplanted with 2.8 × 10(6) same-donor MSCs per kilogram at 8 years of… CONTINUE READING
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