Pre- and postnatal influence of testosterone propionate and diethylstilbestrol on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.

@article{Dhler1984PreAP,
  title={Pre- and postnatal influence of testosterone propionate and diethylstilbestrol on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.},
  author={Klaus D. D{\"o}hler and A. Coquelin and Fred C. Davis and Melissa Hines and J E Shryne and Roger A. Gorski},
  journal={Brain research},
  year={1984},
  volume={302 2},
  pages={291-5}
}
The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is several fold larger in males than in females. When female rats were treated pre- and postnatally with testosterone propionate (TP) or with diethylstilbestrol (DES) they became anovulatory and their SDN-POA developed equivalent in size to that of normal males. Identical treatment of male rats resulted in deficient testicular development, but had no influence on SDN-POA volume. The results indicate… CONTINUE READING
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