Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.

@article{Wei2013PreAP,
  title={Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.},
  author={Bingxin Wei and Tatsuro Kumada and Tomonori Furukawa and Keiji Inoue and Masahiko Watanabe and Katsushige Sato and Atsuo Fukuda},
  journal={Neuroscience},
  year={2013},
  volume={228},
  pages={334-48}
}
Although trigeminal neuropathic pain is one of the most common chronic pain syndromes, the etiology is still unknown. Here, a rat model was generated using chronic constrictive injury (CCI) with ligation of the infraorbital nerve to test the hypothesis that collapse of chloride homeostasis in trigeminal neurons causes impairment of γ-aminobutyric acid-ergic (GABAergic) inhibition and induces trigeminal allodynia. Rats showed a reduction and increase in pain threshold and pain response scores… CONTINUE READING