Pre-analytical conditions for the assessment of circulating MMP-9 and TIMP-1: consideration of pitfalls.

none of these studies had observed tolerance towards subsequent LPS challenge(s) in their healthy human subjects at doses of LPS described that were higher than ours. It is possible that tolerance in healthy nonatopic human subjects only occurs in exposure to lower doses of inhaled endoxin. In fact, existing literature indicates that exposure of 30–40 mg… (More)