Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoid

@inproceedings{lamo2015PreamyloidOO,
  title={Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoid},
  author={Mar{\'i}a Moreno-del {\'A}lamo and Susana Moreno-D{\'i}az de la Espina and MARIA-ELENA FERNANDEZ-TRESGUERRES and Rafael Giraldo},
  booktitle={Scientific reports},
  year={2015}
}
Upon binding to short specific dsDNA sequences in vitro, the N-terminal WH1 domain of the plasmid DNA replication initiator RepA assembles as amyloid fibres. These are bundles of single or double twisted tubular filaments in which distorted RepA-WH1 monomers are the building blocks. When expressed in Escherichia coli, RepA-WH1 triggers the first synthetic amyloid proteinopathy in bacteria, recapitulating some of the features of mammalian prion diseases: it is vertically transmissible, albeit… CONTINUE READING
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The authors declare no competing financial interests

  • Yoshiike, 3 Y.etal.Amyloidoligomerconformationinagroupofnative, +9 authors wrote the manuscript. Additional Information Competing f interests
  • How to cite this article: Moreno-del Álamo, M. et…
  • 2015

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